Holy strawberry floating gooseberry fool
So after a roughly 40 run losing streak as The Lost I finally got somewhere.
It was fairly unremarkable early on. The key item I had was Technology 2, which meant I could kill enemies from a distance fairly safely, even though I had little damage. By Depths 1 I was Guppy, thanks to some favourable Red Chests. However, the fly spawns weren't as much as I was hoping - I figured it'd be constant as Tech 2 hits repeatedly, but it seemed to be a few flies per second, rather than a constant stream.
So anyway, I decided to enter a curse room. I knew I'd die on the way out, but I figured as I had the Dead Cat, I'd just take the loss of 1 life in the hopes of the room being worth it. It wasn't worth it, so I exited, died, and respawned...only I didn't think this through. I respawned INSIDE THE strawberry floating CURSE ROOM. I had no way out. I was resigned to a fate of constantly leaving, dying, respawning and repeat, until the rest of my lives ran out. Wait, though. I have the passage rune which opens a trapdoor to the next floor. I'm saved! Let's just press X and OH FOR strawberry float SAKE IT'S NOT A DOOR TO THE NEXT FLOOR JUST STEPS TO THE SIDESCROLLING ROOM. strawberry float. Sake. So I go down, and in there is something interesting...the D4. Hmmmm. I was thinking of ways this could save me by using it, but nothing came to mind. Sigh. I went back up, used the D4, and continued on my spiky fate until I died. Oh well, I'll just have to start ag...wait a minute. I'm out! THE strawberry floating D4 GAVE ME THE HOLY MANTLE! The only item, that I can think of right now, that would have got me out of there. Not only that, but it rerolled me into having Technology 1, with pretty much as high a tear stat as possible, so this time, I really did have a constant stream of flies spawning. This carried me through to Mom's Heart, to Satan, and The Lamb. YES!
Boss Rush, Cathedral and The Chest to go.